中国科学院广州生物医药与健康研究院孙益嵘团队
个人情况
孙益嵘，中科院广州生物医药与健康研究院副研究员，博士毕业于日本千叶大学，曾在美国加州大学洛杉矶分校访学。开展微生物与细胞微环境、天然免疫、合成生物学研究。发表论文十余篇，申请专利3项，获批1项，主持国家及省部级项目5项。获“第六届中国创新挑战赛（湖北生物医药专场）”二等奖。
团队情况
团队成员包括1名正高级研究人员，2名副高级研究人员，1名中级研究人员，以及2名博士生以及2名硕士生。
研究方向
团队围绕微生物合成、细胞免疫治疗开展研究工作，主要通过改造微生物、免疫细胞，合成天然产物和细胞成分、利用天然免疫和改造T细胞免疫治疗肿瘤。
取得的成果
代表论著：
(1) Rui Tang; Wei Sun; Ji-Chun Zhang; Liufeng Mao; Natalie Quanquin; Donghai Wu; Yirong Sun*;Expression of Human Uncoupling Protein-1 in Escherichia coli Decreases its Survival Under Extremely Acidic Conditions, Current Microbiology, 2022, 79(3): 77-87 (期刊论文)
(2) Tang, Rui; Cao, Qian-qian; Hu, Sheng-wei; He, Lu-juan; Du, Peng-fei; Chen, Gang; Fu, Rao;Xiao, Fei; Sun, Yi-rong*; Zhang, Ji-chun*; Qi, Qi*; Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription, Acta Pharmacologica Sinica,2021, 0: 1-11 (期刊论文)
(3) Bai, Yi-ling; Chen, Yun-hui; Jiang, Cui; Qian, Jun-hui; Han, Ling-ling; Lu, Hai-zhen; Wang, Hao-zhong; Sun, Yi-rong*; Efficacy and Safety of Traditional Chinese Medicine in the Treatment of Immune Infertility Based on the Theory of "Kidney Deficiency and Blood Stasis": A Systematic Review and Meta-Analysis,Evidence-Based Complementary and Alternative Medicine, 2021, 2021(9947348) (期刊论文期刊论文)
(4) Zhang, Wenbin; Chen, Xin; Sun, Wei; Nie, Tao; Quanquin, Natalie; Sun, Yirong*; Escherichia coliIncreases its ATP Concentration in Weakly Acidic Environments Principally through the Glycolytic Pathway, Genes, 2020, 11(9): 991 (期刊论文)
(5) Xu, Shuo; Zhai, Dongsheng; Wang, Feifei; An, Xin; Pang, Hongshen; Sun, Yirong; A novel method for topic linkages between scientific publications and patents, Journal of the Association for Information Science and Technology, 2019, 70(9): 1026-1042 (期刊论文)
(6) Nie, Tao; Zhao, Shiting; Mao, Liufeng; Yang, Yiting; Sun, Wei; Lin, Xiaoliang; Liu, Shuo; Li, Kuai; Sun, Yirong; Li, Peng; Zhou, Zhiguang; Lin, Shaoqiang; Hui, Xiaoyan; Xu, Aimin; Ma, Chung Wah; Xu, Yong; Wang, Cunchuan; Dunbar, P Rod; Wu, Donghai ; The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPAR gamma activity, British Journal of Pharmacology, 2018, 175(9): 1439-1450 (期刊论文)
(7) Yirong Sun*; Wenbin Zhang; Jincheng Ma; Hongshen Pang; Haihong Wang*; Overproduction of α-Lipoic Acid by Gene Manipulated Escherichia coli, PLoS One, 2017, 12(1) (期刊论文)
(8) Yirong Sun*; F1F0-ATPase Functions Under Markedly Acidic Conditions in Bacteria, Springer International Publishing, 2016 (学术专著)
(9) Sai-Xiang Feng; Jin-Cheng Ma; Ji Yang; Zhe Hu; Lei Zhu; Hong-Kai Bi; Yi-Rong Sun; Hai-Hong Wang*; Ralstonia solanacearum fatty acid composition is determined by interaction of two 3-ketoacyl-acyl carrier protein reductases encoded on separate replicons, BMC Microbiology, 2015, 15(223) (期刊论文)
(10) Yirong Sun; Toshihiko Fukamachi; Hiromi Saito; Hiroshi Kobayashi*; Adenosine deamination increases the survival under acidic conditions in Escherichia coli, Journal of applied microbiology, 2012, 112(4): 775-781 (期刊论文)
(11) Yirong Sun; Toshihiko Fukamachi; Hiromi Saito; Hiroshi Kobayashi*; ATP requirement for acidic resistance in Escherichia coli, Journal of Bacteriology, 2011, 193(12): 3072-3077 (期刊论文)
专利和学术奖励：
(1) 李素霞; 孙益嵘; 王菲; 马燕; 张咪咪; 王可; 陆林; 时杰 ; 免疫细胞因子白介素-22在制备抗抑郁药物中的应用, 2021-1-5, 中国, CN202110007018.4 (专利)
(2) 孙益嵘; 王海洪; 庞弘燊; 何伟 ; α-硫辛酸的生物合成方法、工程菌株及其制备方法, 2013-9-17,中国, CN201310425941.5 (专利)
(3) 孙益嵘团队; 第六届中国创新大赛, 中国创新挑战赛组委会, 其他, 省部二等奖, 2021 (科研奖励)
